Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant and Molecular Docking Studies of Polyfunctional Substituted Azoles, Azines, and their Analogs linked Sulfamethoxazole moiety.

Mousa, Ibrahim Abdel-motaleb; El-Maghraby, Awatef M.; Hassane, Abdallah M. A.; Gaafar, Hatem; Yahya, Muhammad E.; Hussein, Abdelhaleem M

doi:10.21608/ejchem.2024.286549.9673

Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant and Molecular Docking Studies of Polyfunctional Substituted Azoles, Azines, and their Analogs linked Sulfamethoxazole moiety.

Document Type : Original Article

Authors

¹ Chemistry department-Faculty of science- South valley university- Qena - Egypt

² Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt

³ Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Assiut

⁴ national research center/EGYPT

⁵ Department of chemistry, faculty of science, south valley university

⁶ Department of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, Egypt

10.21608/ejchem.2024.286549.9673

Abstract

A new series of substituted azoles, azines, and their analogs linked sulfamethoxazole moiety was designed and synthesized. The antioxidant activity study of our synthesized compounds and molecular docking enhancement were achieved. Moreover, the antimicrobial assay indicated that compound 1 is the more active compound against all the stains compared to the reference drugs. So, reactions of β-oxobutanamide derivative 1 with different reagents afforded compounds 2a,b, 5, 7 and 8 12 and 14. Coupling of 1 with diazonium salt yield aryl hydrazones 10a,b which reacts with ethyl chloroformate to yield the triazinediones 11a,b. Reactions of enaminone 12 with some electrophilic and nucleophilic reagents to yield compounds 16, 21, 22, 23, 24 and 25 respectively. The structures of all compounds were characterized by means of spectral and elemental analyses.

Keywords