Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials

Document Type : Original Article

Authors

1 Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O: Box: 21934, Alexandria, Egypt

2 Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt, email: yossry@yahoo.com

3 2Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt

4 City of Scientific Research and technological applications (SRTA

5 City of Scientific Research and technological applications (SRTA)

Abstract

The research on biopolymers and its derivatives has received much attention from the researchers toward preparing a novel material. The biopolymers and its derivatives have broad applications due to its biodegradability, nontoxicity and biocompatibility. The present study aimed to develop and characterizes a unique chitosan Schiff base by coupling chitosan with isatin under acidic conditions to form isatin/chitosan Schiff base. The changing in chitosan chemical structure was proved by FT-IR, electronic spectra. The physico-chemical study shows a decrease of samples water uptake and solubility in aqueous acidic solution by increased isatin content as a result of an increase in hydrophobicity character of chitosan by modification. Antibacterial activity was tested against four different bacterial strains one gram-positive: (Staphylococcus aureus) and three gram negative (Pseudomonas aeruginosa, Salmonella and Proteus vulgaris). The results showed increases in the antibacterial activity of substituted chitosan against both gram-negative and gram-positive bacteria by the rise in isatin content.

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History

  • Receive Date: 29 January 2019
  • Revise Date: 14 April 2019
  • Accept Date: 25 June 2019

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