Influence of Poloxmer on the Dissolution Properties of Mosapride and Its Pharmaceutical Tablet Formulation

This work was an attempt to improve therapeutic efficacy and increase patient compliance thereby formulating immediate release of Mosapride citrate’s tablets with improved physical and chemical characteristics. The tablet form was prepared by wet granulation of Mosapride with a binder solution of Poloxmer 407 and compressed the dried granules of Mosapride into non-friable, stable tablets. The other objective, the performance of two classes of superdisintegrants as croscarmellose sodium (Ac-Di-Sol), and sodium starch glycolate (Primojel) in dissolution of Mosapride immediate release and promoting disintegration tablets was evaluated. The post-compression and the pre-compression parameters were characterized which within their respective standards must lie. Chemical composition and crystallinity were investigated via FTIR and XRD, respectively. The post compression parameters such as thickness test, hardness, friability testes and in vitro drug release studies were also performed.