Cellulose Sulfate: A Fascinating Anticoagulant Material

Kamel, Samir

doi:10.21608/ejchem.2024.281505.9553

Cellulose Sulfate: A Fascinating Anticoagulant Material

Document Type : Review Articles

Author

Samir Kamel

Cellulose and Paper Department. Chemical Industral Research Division, National Research Centre, 33 El Bohouth St. (former El Tahrir st.), Dokki, Giza,Egypt, P.O. 12622

10.21608/ejchem.2024.281505.9553

Abstract

Anticoagulants have been extensively employed in in vitro medical therapies and therapeutic procedures. In clinical applications, heparin is most frequently used, but regrettably, it has specific adverse effects, including bleeding and other drawbacks (heterogeneity and fluctuation of anticoagulant action). In addition, the isolation of heparin from animal sources increases the possibility of contamination by animal infections. Thus, the creation of heparin substitutes is a crucial area of study. One of the better options is a structurally well-defined, nonmammalian source of heparin derivative, polysaccharide sulfates being of particular interest. The most prevalent polysaccharide on Earth is cellulose. The discovery of novel uses for this adaptable material is facilitated by its inherent abundance. Cellulose can exist in different morphological forms: ﬁber, micro/nanocrystalline, and microﬁbril/nanoﬁbril cellulose. This review extensively surveys sulfated cellulose preparation and its potential anticoagulation agent use.

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