Document Type : Original Article
Authors
1
aDepartment of Chemistry, Acharya Nagarjuna University, N Nagar-522 510, Andhra Pradesh, India
2
Faculty of Data Science and Information Technology, INTI International University, 71800 Nilai, Malaysia
3
Department of Chemistry, Acharya Nagarjuna University, N Nagar-522 510, Andhra Pradesh, India
4
Department of Chemistry, Andhra Kesari University-523001, Ongole, Andhra Pradesh, India
Abstract
Doxorubicin, an anthracyline medication, is regularly used to treat a number of malignancies, including sarcoma, lung, breast, gastric, thyroid, non-Hodgkin's lymphoma, ovarian, Hodgkin's lymphoma, multiple myeloma, and childhood cancers. One unidentified doxorubicin impurity with an RRT of 1.23 and a concentration higher than 0.1% was discovered during the quality inspection of doxorubicin in bulk forms. By thoroughly analysing the 1D-NMR (1H) spectroscopic data and the LC-MS mass ionization spectrum data, the structure and molecular mass of the unknown doxorubicin impurity with an RRT of 1.23 were determined. From spectroscopic data and the LC-MS mass ionization spectrum data, it was also observed that doxorubicin and unknown doxorubicin impurity with an RRT of 1.23 are interconvertible.
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