The importance of serum fibroblast growth factor-23 in obesity and metabolic syndrome, Potential effect of nutritional therapy intervention

Document Type : Original Article


1 Department of Nutrition and Food Science, National Research Center, Cairo, Egypt

2 Nutrition and Food Sciences, National Research Centre, Egypt

3 Food Technology Dept., National Research Centre, El-Buhouth St., Dokki, Cairo, Egypt


Background: Fibroblast growth factor-23, a hormone, regulates circulating phosphate and vitamin D levels and also plays a role in some metabolic processes. Objective: A food supplement containing Moringa oleifera leaf flour and turmeric powder has been used in conjunction with a low-calorie diet to help people lose weight and improve metabolic and renal problems. Subjects and methods: Two-phase interventional study that lasted 8 weeks. Sixty-four volunteer women with varying degrees of obesity and metabolic syndrome criteria took part. Their mean age and BMI were 47.37± 1.31 years and 36.50±0.68 kg/m2, respectively. All participants followed a low caloric balanced diet for eight weeks. They ate moringa pies during the first phase and the regimen during the second. Patients were clinically, anthropometrically , dietary 24 h recall and biochemically monitored. Results: At the end of the first phase, there was a significant reduction in the mean values of the anthropometric and more in the biochemical parameters, which began to fade in the second phase. FGF-23 and various metabolic parameters were found to have negative significant correlations both at baseline and after intervention. Creatinine and IL1β showed a significant positive correlation but a significant negative correlation with eGFR. Conclusion: As a bakery product, the health effect of a dietary therapy supplemented with pies fortified with Moringa oleifera leaf and turmeric powder as anti-inflammatory and antidiabeic was demonstrated. The inverse relationship detected in this study between FGF-23 and metabolic syndrome parameters were suggested to maintained serum phosphorus hemostasis. Because of the link between FGF-23, creatinine, and eGFR, it could be used as a valuable factor in kidney function research.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 12 May 2024
  • Receive Date: 31 January 2024
  • Revise Date: 04 May 2024
  • Accept Date: 12 May 2024