Potential anticancer, antiviral and antimicrobial effect of Red Sea soft coral.

Abdel-Tawab, Asmaa M.; Hamed, El Sayed A. E.; Abouelkheir, Samia S.

doi:10.21608/ejchem.2024.251493.8928

Potential anticancer, antiviral and antimicrobial effect of Red Sea soft coral.

Document Type : Original Article

Authors

¹ National Institute of Oceanography and Fisheries (NIOF), Egypt, Marine Biotechnology and Natural Products Laboratory.

² Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt.

³ National Institute of Oceanography and Fisheries (NIOF), Egypt, Invertebrate Aquaculture Laboratory

⁴ National Institute of Oceanography and Fisheries (NIOF), Egypt, Microbiology Laboratory.

10.21608/ejchem.2024.251493.8928

Abstract

Sarcophyton Convolutum extract (S) is rich source of bioactive secondary metabolite. In this article we report identification of major components and study antimicrobial, anticancer and antiviral activities of non-polar Sarcophyton Convolutum extract. Results demonstrated that S. Convolutum extract (S) has strong bactericidal effect against P. aeruginosa ATCC 15442 recording MIC value about 0.05µg/mL. S. Convolutum extract (S) showed cytotoxicity against hepatocellular carcinoma cell line (HepG2), human colorectal adenocarcinoma (CaCo2), breast cancer cell line (MCF-7), and pulmonary adenocarcinoma (A549) and recorded IC50 of 102.73, 100.62, 86.68 and 81.64 while antiviral activity towards HSV-1 and HAV virus at the maximum nontoxic concentration was 32.69% and 11.53%, respectively. GCMS analysis of S. Convolutum extract (S) showed about 25 compounds about 45.31% of extract is sesquiterpene, 47.53 % fatty acid derivatives 3.13% steroids and 2.2% is retinal diterpene. Our in vitro study indicates that sesquiterpene rich softcoral S. Convolutum extract (S) is a promising anticancer and antimicrobial agent but weak antiviral agent.

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