New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect

Soliman, Zainab Adel; Kamel, Emadeldin Mohamed; Hosny, Mona Amin; الفرارجي, احمد فؤاد; Mokbel, Wafaa Abd El Badi

doi:10.21608/ejchem.2024.275486.9423

New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of women for Arts, Science and Education, Ain Shams University

² Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.

³ Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.

⁴ أستاذ الکيمياء العضوية-کلية العلوم -جامعة الزقازيق

10.21608/ejchem.2024.275486.9423

Abstract

Abstract

1,2,4-Triazole-3-thiols have recently garnered sufficient concern due to their cytotoxic and antimicrobial properties, rendering them valuable in aspects of medicine and pharmacology. The interaction of phenyl hydrazine and benzoyl isothiocyanate (1) yielded 1,5-diphenyl-1H-1,2,4-triazole-3-thiol (2), which upon treatment with hydrazine monohydrate after exposure to ethyl-chloroacetate, acetohydrazide (4) was achieved, that was taken into consideration as a raw substance for creating new derivatives (5–9) by interacting with carbon disulfide, isatin, glucose, phthalic anhydride, and various aldehydes. The spectroscopic analysis encompassing (IR, Mass spectrum, 1H-NMR, and 13C-NMR) for those newly synthesized compounds and their behavior against bacteria, fungi, and breast cancer cell lines are covered in this study. Moreover, molecular docking investigation of the antimicrobial action and the structure-activity relationships SAR based on cytotoxic impact are mentioned and discussed.

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