New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect

Document Type : Original Article


1 Chemistry Department, Faculty of women for Arts, Science and Education, Ain Shams University

2 Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.

3 Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.

4 أستاذ الکيمياء العضوية-کلية العلوم -جامعة الزقازيق



1,2,4-Triazole-3-thiols have recently garnered sufficient concern due to their cytotoxic and antimicrobial properties, rendering them valuable in aspects of medicine and pharmacology. The interaction of phenyl hydrazine and benzoyl isothiocyanate (1) yielded 1,5-diphenyl-1H-1,2,4-triazole-3-thiol (2), which upon treatment with hydrazine monohydrate after exposure to ethyl-chloroacetate, acetohydrazide (4) was achieved, that was taken into consideration as a raw substance for creating new derivatives (5–9) by interacting with carbon disulfide, isatin, glucose, phthalic anhydride, and various aldehydes. The spectroscopic analysis encompassing (IR, Mass spectrum, 1H-NMR, and 13C-NMR) for those newly synthesized compounds and their behavior against bacteria, fungi, and breast cancer cell lines are covered in this study. Moreover, molecular docking investigation of the antimicrobial action and the structure-activity relationships SAR based on cytotoxic impact are mentioned and discussed.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 15 April 2024
  • Receive Date: 08 March 2024
  • Revise Date: 01 April 2024
  • Accept Date: 15 April 2024