Quinazolines Linked to Sugar Derivatives as Nucleoside Analogs, Synthesis and Biological Aspects

Abdel-Rahman, Adel A.-H.; El-Ganzoury, Eman M.; Zeid, Ibrahim F.; Zayed, Ehab M.; El-Sayed, Wael A.

doi:10.21608/ejchem.2024.259301.9116

Quinazolines Linked to Sugar Derivatives as Nucleoside Analogs, Synthesis and Biological Aspects

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt

² Green Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

³ Photochemistry Department, National Research Centre, Dokki, Giza, Egypt

10.21608/ejchem.2024.259301.9116

Abstract

Quinazoline incorporating compounds have recently acquired intensive interest due to their several applications, the most important of which are those related to the divers bioactivities. Quinazoline derivatives have a variety of pharmacological effects providing a special interest to such heterocyclic systems as a basic core in bioactive structures. Techniques for synthesizing or modifying this ring structure are therefore always evolving and intriguing. As intermediates in the synthesis of various beneficial heterocyclic compounds, they are of considerable interest. Incorporation of sugar, in modified cyclic and acyclic forms, with the structure of heterocyclic possessing quinazoline system revealed potential structures with various bioactivities.

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