Synthesis and Characterization of Novel Phthalazin-1(2H)-one Hybrids with Anticipated Antibacterial Activity

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt

2 Department of Chemistry, Faculty of Science, Fayoum University,Fayoum-Egypt

3 Department of chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt

Abstract

Herein, a phthalazine acetohydrazide derivative 4 was assembled and its behaviour towards carbon nucleophiles was thoroughly investigated. Subsequently, phthalazine derivative 4 was used as a valuable scaffold for synthesizing assorted heterocycles such as pyrazol, thiazolidine, and azetidine. Diversified reaction conditions and reagents were explored. The assigned structures of the assembled heterocycles were elucidated utilizing IR, 1H NMR, 13C NMR, MS, and elemental analysis. Finally, the newly assembled heterocycles were evaluated in vitro for their antibacterial activities.

Keywords

Egyptian Journal of Chemistry

Articles in Press, Accepted Manuscript
Available Online from 16 January 2024

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History

  • Receive Date: 25 December 2023
  • Revise Date: 09 January 2024
  • Accept Date: 25 January 2024

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