Comparative study between an electrospun fibrous copolymer and their single polymers: synthesis, characterization and cell growth

Ismail, Naglaa M; Korraa, Soheir S; Osman, Massrat B; Elsheikh, Eman

doi:10.21608/ejchem.2023.228733.8414

Comparative study between an electrospun fibrous copolymer and their single polymers: synthesis, characterization and cell growth

Document Type : Original Article

Authors

¹ Physics department – Faculty of Women for Arts, Science and Education - Ain Shams University

² Radiation Health Department- National Center for Radiation Research and Technology – Atomic Energy Authority, Egypt

10.21608/ejchem.2023.228733.8414

Abstract

Electrospun Fiber matrices fabricated from biopolymers have been shown too successfully to provide scaffolds for cell attachment and proliferation, so this study aimed to fabricate PCL, PLA scaffolds and their copolymer; PCL/PLA in the fiber form by using the electrospinning technique. Where, nanofiber (PCL/PLA) scaffold could be prepared by adding the dissolved solutions of 10% (PCL) to 10% (PLA) with a ratio 4:1 then applying this mixture into electrospinning to turn the dissolved solution into a fiber form. FTIR and XRD techniques were used to investigate the formation of electrospun nanofiber PCL/PLA (4:1) scaffold. Finally, scanning electron microscope images was used to observe the scaffold fibers before and after cell transplantation and it was concluded that PCL/PLA copolymer scaffold provided highest proliferation of Vero cells followed by PCL scaffolds then PLA that referred to its high biocompatibility with the cells compared to their single components PCL and PLA electrospun fiber scaffolds.

Keywords