Utilization of Multi Component Reactions in the Synthesis of 1,6-Naphthyridine Derivatives with Expected Biological Activity

Abdullah Alzahrani, Abdullah Y.; Atef, Amira; Derafa, Wassila; Morsy, Nesrin M.

doi:10.21608/ejchem.2023.239412.8682

Utilization of Multi Component Reactions in the Synthesis of 1,6-Naphthyridine Derivatives with Expected Biological Activity

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail Assir, Saudi Arabia

² Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

³ bChemistry Department, College of Science, Jouf University, Sakaka 2014, Saudi Arabia

⁴ Organometallic and Organometalloid Chemistry Department,National Research Centre, Cairo,12622, Dokki, Egypt.

10.21608/ejchem.2023.239412.8682

Abstract

We have achieved the diastereo selective synthesis of pyrano and furano naphthyridine derivatives through the utilization of Camphor sulfonic acid (CSA) as a catalyst in an ABB' type multi component coupling reaction involving 4-aminopyridine and cyclic enol ethers to form of pyrano and furano naphthyridine in high yields, primarily exhibiting cis diastereo selectivity. Notably, the addition of water as a reagent causes a shift in diastereoselectivity towards the trans isomer. Synthesized compounds were evaluated in vitro for their antimicrobial activities and molecular docking studies were performed.

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