Utilization of Multi Component Reactions in the Synthesis of 1,6-Naphthyridine Derivatives with Expected Biological Activity

Document Type : Original Article


1 Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail Assir, Saudi Arabia

2 Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

3 bChemistry Department, College of Science, Jouf University, Sakaka 2014, Saudi Arabia

4 Organometallic and Organometalloid Chemistry Department,National Research Centre, Cairo,12622, Dokki, Egypt.


We have achieved the diastereo selective synthesis of pyrano and furano naphthyridine derivatives through the utilization of Camphor sulfonic acid (CSA) as a catalyst in an ABB' type multi component coupling reaction involving 4-aminopyridine and cyclic enol ethers to form of pyrano and furano naphthyridine in high yields, primarily exhibiting cis diastereo selectivity. Notably, the addition of water as a reagent causes a shift in diastereoselectivity towards the trans isomer. Synthesized compounds were evaluated in vitro for their antimicrobial activities and molecular docking studies were performed.


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