Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice

Hamdy, Soha M.; Moawad, Basma M.; Mohamed, Heba R.; Shabaan, Amany M.; Sayed, Ola N.

doi:10.21608/ejchem.2023.238561.8657

Anticancer Potential of Blue-Green Algae Extract (Spirulina Plantesis) and Curcumin Nanoparticles on Ehrlich Ascites Carcinoma–Bearing Mice

Document Type : Original Article

Authors

¹ Chemistry Department, Biochemistry Division, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.

² Zoology Department, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.

10.21608/ejchem.2023.238561.8657

Abstract

Abstract

This research was accomplished to identify the possibility of preventing cancer by Spirulina plantesis (SP) and curcumin nanoparticles (Cur-NPs) being natural substances in the EAC model. 110 male mice were split up randomly into group (I): healthy control; group (II): mice received SP; group (III): mice received Cur-NPs; group IV: mice administrated with both SP and Cur-NPs; group V: EAC group; group VI: SP Protective (Pr) group; group VII: SP Therapeutic (Tr) group; group VIII: Cur-NPs Pr group; group IX: Cur-NPs Tr group; group X: SP & Cur-NPs Pr group; group In comparison to the control group, the biochemical assays throughout this study exhibited an extremely significant rise in serum and hepatic MDA, ALT, and AST levels and a greatly marked drop in levels of TAC in the EAC group. In contrast, administration of Cur-Nps alone or combined with SP results in a significant reduction and improvement in their levels. The histological and immunohistochemical findings confirm the biochemical observations since the liver's histology and immunohistochemistry were improved by SP and Cur-NPs.

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