Synthesis, characterization, biological, anticancer and antialzahimar activities studies of ternary pd(II) complexes

Document Type : Original Article


1 Basic Science Department, Modern Academy for Engineering and Technology, Egypt

2 Faculty of science, Cairo university

3 chemistry, faculty of science, Cairo university


This paper details the synthesis and spectral characterization of novel Pd (II) coordination ternary metal complexes. These complexes are formed using Cefradine as the primary ligand and aromatic amines as secondary ligands. The identification of these new ternary metal complexes involves a comprehensive array of spectrophotometric and physico-chemical analyses, including elemental analysis, infrared spectroscopy (IR), proton nuclear magnetic resonance (1H NMR) spectroscopy, melting point determination, conductivity measurements, mass spectrometry, and thermal analysis (TG and DTG). Furthermore, the antimicrobial activity of these complexes was assessed against a range of microorganisms, including Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus, Gram-negative bacteria including Salmonella species and E. coli, as well as fungi like Candida albicans and Aspergillus fumigatus. To gauge their effectiveness, the complexes were compared to well-known standards in the field: amikacin, an antibacterial agent, and ketoconazole, an antifungal agent. Remarkably, the Pd (II) ternary complexes exhibited noteworthy activity as potential anti-Alzheimer's drugs. Additionally, the paper explores the anticancer properties of the ligands and their corresponding metal complexes using viability assays against human cancer cells (MCF-7 cells). These prepared palladium complexes, which demonstrate high selectivity for acetylcholinesterase (AChE), warrant further investigation as potential candidates for the treatment of early-stage Alzheimer's disease symptoms.