In the present work is concerned with preparation, separation and structure elucidation of solid ion-pairs of three antifungal drugs Fluconazole (FLZ), Voriconazole (VRZ) and Butoconazole nitrate (BTZ) with Rose Bengal (Rbeng). The solid ion-pairs were prepared and investigated using FT-IR, mass spectral (MS) and thermal analyses (TA), in addition to elemental analysis (EA). The general formulae of the prepared ion-pairs were determined. Moreover, the formulae of prepared ion-pairs were proposed and structurally identified. The biological activities of the separated solid ion-pairs towards five types of bacteria and one type fungi in comparison with their drugs were studied, and they were found to be biologically active more than their parent drugs.
Zayed, M., & Abdallah, M. A. (2019). Structure Investigation of Solid Ion Pairs of Three Azole Drugs-rose Bengal Using Different Spectroscopic Techniques and their Biological Activities. Egyptian Journal of Chemistry, 62(11), 2143-2162. doi: 10.21608/ejchem.2019.11907.1750
MLA
Mohamed Zayed; Marwa A. Abdallah. "Structure Investigation of Solid Ion Pairs of Three Azole Drugs-rose Bengal Using Different Spectroscopic Techniques and their Biological Activities". Egyptian Journal of Chemistry, 62, 11, 2019, 2143-2162. doi: 10.21608/ejchem.2019.11907.1750
HARVARD
Zayed, M., Abdallah, M. A. (2019). 'Structure Investigation of Solid Ion Pairs of Three Azole Drugs-rose Bengal Using Different Spectroscopic Techniques and their Biological Activities', Egyptian Journal of Chemistry, 62(11), pp. 2143-2162. doi: 10.21608/ejchem.2019.11907.1750
VANCOUVER
Zayed, M., Abdallah, M. A. Structure Investigation of Solid Ion Pairs of Three Azole Drugs-rose Bengal Using Different Spectroscopic Techniques and their Biological Activities. Egyptian Journal of Chemistry, 2019; 62(11): 2143-2162. doi: 10.21608/ejchem.2019.11907.1750
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