Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent

Mohamed, Ayda A.; Ayad, D.M.; Al-Subbagh, H.; Abdelaal, M.Y.

doi:10.21608/ejchem.2023.214817.8068

Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

² Faculty of Pharmacy, Horus University in Egypt, New Damietta, Egypt

³ Medicinal Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

10.21608/ejchem.2023.214817.8068

Abstract

In the current work, 4-nitroaniline (1) reacted with sodium azide to produce 4-nitrophenyl azide (2) and converted into the corresponding 1,2,3-triazole derivative (3). The obtained 1,2,3-triazole derivative (3) converted into (E)-1-[5-methyl-1-(4-nitrophenyl)triazol-4-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (4) through Claisen-Schmidt condensation with 3,4,5-trihydroxybenzaldehyde in ethanolic NaOH. Compound 4 was then characterized with the suitable spectroscopic techniques and investigated for its anticancer activity. Blends of 4 with Chitosan (CS) and carboxymethylcellulose (CMC) were prepared by uploading it into the polymer matrices through physical mixing. The release behavior of 4 from the polymer blends into an aqueous medium at room temperature was investigated and discussed.

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