Characterization, optimization, and physicochemical characteristics of polyvinyl alcohol containing sulfa drug

Abdelghany, A.M.; Elashmawi, I. S.; Abobakr, Sohier M.; Hegazi, M.M.; Abouelnaga, Zeinab S.

doi:10.21608/ejchem.2023.217364.8134

Characterization, optimization, and physicochemical characteristics of polyvinyl alcohol containing sulfa drug

Document Type : Original Article

Authors

¹ Spectroscopy Department, Physics Research Institute, National Research Centre, ElBehouth St., 12311, Dokki, Giza, Egypt

² Higher Institute of Engineering and Technology, New Damietta, 34517, Egypt

³ Department of Basic Science, Mansoura Higher Institute of Engineering and Technology, Mansoura, Egypt

⁴ Zoology Department, Faculty of Science, Mansoura University, 35516, Mansoura, Egypt

10.21608/ejchem.2023.217364.8134

Abstract

A new sulfonamide adduct of vitamin C has been created to improve the structural and optical properties of polyvinyl alcohol (PVA) films. PVA films containing different concentrations of sulfa drugs have been prepared and characterized using FT-IR and UV-Vis spectroscopy. The FT-IR absorption spectrum of pure PVA polymer shows characteristic bands related to the functional groups present in the PVA polymer. The FT-IR data demonstrated strong chemical interactions between the functional groups within the hybrid PVA. The FT-IR spectra of PVA films containing sulfa drugs confirmed the presence of the drug in the polymer matrix. The drug-specific bands, such as the sulfonamide group (SO2NH2), were observed. The intensity of these bands can be used to estimate the drug loading efficiency and drug content in the PVA films. The UV-vis spectra mainly characterized the optical properties of the hybrid film. The extinction coefficient (k) values were significantly elevated. The direct and indirect electronic transition between the valence band and conduction band was determined using Tauc's model. Based on these preliminary results, the flexible composite has great potential for use in antibacterial applications.

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