Synthesis and Characterization of Hydrogel Alginate/Poly (N-Vinyl -2-Pyrrolidone) with Double Ionic Cross-Bonded for Drug Delivery and Antibacterial Agent

Document Type : Review Articles


Department of Analytical Chemistry, Polytechnic of AKA Bogor, Jalan Pangeran Sogiri No. 283, Bogor 16154, Indonesia


Alginate (Alg), as a biopolymer has suitable characteristics for drug delivery systems, quickly forming gel with polyvalent cations, and compatible with another polymer like poly (N-vinyl-2-pyrrolidone) (PVP). In this study, the synthesis of Alg/PVP hydrogels with calcium and strontium ion crosslinkers has been carried out and characterized with Fourier Transform Infrared (FTIR) and Scanning Electron Microscope Energy Dispersive X-ray (SEM EDX. The research studies the expansion ratio (swelling), percent gel, antibacterial test of the hydrogel, and the application of the hydrogel in drug delivery systems through dissolution tests. The results of the synthesis of Alg/PVP/Ca/Sr hydrogels obtained the development ratio (swelling, Q%) and percent gel (G%) with crosslinking of Ca2+ and Sr2+ ions optimum at 70:30 Alg/PVP ratio and 2:3 Ca/Sr ratio, with a Q% value of 448.47%±4.19 and a G% value of 18.25%±0.05. Hydrogel has antibacterial properties against Bacillus subtilis and Escherichia coli. Hydrogels can also be used as drug delivery mediums, with dissolution test results for amoxycillin at 46.18% ±1.50 and ibuprofen at 94.83%±0.50.