Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones

Document Type : Original Article

Authors

1 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt.

Abstract

Antibacterial agents structurally based on quinazolin-4-one pharmacophore, have been designed and synthesized. Where the targeted compounds 5a, c and 6a-c were in vitro screened against three gram positive and three gram negative bacteria strains compared to ciprofloxacin as reference drug. Most of compounds had moderate antibacterial activity while compound 5c showed the most significant activity and could be considered as a new lead compound for antibacterial drug design.

Keywords

Main Subjects


Volume 65, Issue 132 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part B)
December 2022
Pages 1547-1551
  • Receive Date: 17 July 2019
  • Revise Date: 08 August 2019
  • Accept Date: 12 March 2023