Antibacterial agents structurally based on quinazolin-4-one pharmacophore, have been designed and synthesized. Where the targeted compounds 5a, c and 6a-c were in vitro screened against three gram positive and three gram negative bacteria strains compared to ciprofloxacin as reference drug. Most of compounds had moderate antibacterial activity while compound 5c showed the most significant activity and could be considered as a new lead compound for antibacterial drug design.
Emam, A., Kothayer, H., Ibrahim, S., & El-Sadek, M. (2022). Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones. Egyptian Journal of Chemistry, 65(132), 1547-1551. doi: 10.21608/ejchem.2023.14892.1905
MLA
Aya M. Emam; Hend Kothayer; Samy M. Ibrahim; Mohamed El-Sadek. "Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones", Egyptian Journal of Chemistry, 65, 132, 2022, 1547-1551. doi: 10.21608/ejchem.2023.14892.1905
HARVARD
Emam, A., Kothayer, H., Ibrahim, S., El-Sadek, M. (2022). 'Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones', Egyptian Journal of Chemistry, 65(132), pp. 1547-1551. doi: 10.21608/ejchem.2023.14892.1905
VANCOUVER
Emam, A., Kothayer, H., Ibrahim, S., El-Sadek, M. Synthesis and Antibacterial Evaluation of New developed 2,3-Dihydroquinazolin-4(1H)-ones. Egyptian Journal of Chemistry, 2022; 65(132): 1547-1551. doi: 10.21608/ejchem.2023.14892.1905
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