Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Saeed, Zainab Faiyq; Saleh, Mohanad Yakdhan; Sadeek, Ghufran Thanoon

doi:10.21608/ejchem.2022.132916.5870

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Document Type : Original Article

Authors

¹ Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul

² Department of Chemistry, College of Education for pure science, University of Mosul

³ department of chemistry, college of Education for pure science

10.21608/ejchem.2022.132916.5870

Abstract

In this paper, a new series of substituted 1, 2,4-triazines was prepared by reacting 4-amino sulfanilic acid with substituted benzaldehyde to form the corresponding Schiff base compounds (1-5), and then reacting two moles of O-methoxy benzaldehyde with hydrazine to form a compound (6) and these compounds reacted with Schiff base (1-5) by applying the Diels-alder reaction in the presence of benzene as a solvent and refluxed it to cyclized into substituted of 1,2,4- triazines derivatives (7-11). Depending on the physical and spectroscopic properties of the prepared compounds that were identified, infrared spectroscopy and nuclear magnetic resonance were used. An evaluation of the biological activity of the prepared compounds was conducted and it gave anti-bacterial results, such as gram-positive and gram-negative when compared with known antibiotics.

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