Organometallic Ester Compounds as a Promising Source of New Antimicrobial Drugs

Document Type : Original Article


1 Department of Chemistry, Faculty of Science, Menoufia University

2 Department of Chemistry, Faculty of Science, Menoufia University, Shebin El -Kom, Egypt

3 Faculty of Science,Menoufia University

4 Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El Kom, Egypt

5 Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Menoufia University, Shebin Elkom, 32511, Egypt


Mono organometallic compounds of Cu(II), Mn(II), Pb(II), Zn(II), Cd(II), Co(II), Ni(II) and Mg(II) of new diethyl 3-((2-aminophenyl)carbamoyl)-3-hydroxypentanedioate ligand have been synthesized and characterized using spectral analyses; (1H-NMR, mass, IR, UV-VIS and ESR) , magnetic moments , conductance, elemental and thermal analysis. Amide ligand metal complex exhibit fluorescent properties. This approach relied on measurement the native fluorescence of the prepared ligand and its metal complexes. The emitted fluorescence was measured at 580 nm after excitation at 415 nm. The fluorescent intensity was proportional to different concentrations of the obtained Cu(II) complex (4) in the linear range of (3.0 x 10-6 to 2.9 x 10-4). Molar conductances in DMF solutions indicated that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (3-5) showed an axial type symmetry indicating a d(x2-y2) ground state with a significant covalent bond character. However, Mn(II) complex (6), showed an isotropic type confirming an octahedral geometry. Cytotoxic evaluation of the complexes as antimicrobial agents has been carried out; the order of inhibitory effect against Gram positive and Gram negative strains for Streptococcus aureus was (13)> (14,control)> (12)> (4,15)> (5)> (3,11)> (6,7)> (2,8)> (9)> (16) ,for B. subtilis the order of cytotoxic effect is (4)> (13)> (3,5,10) > (2,14,control)> (12)> (15)> (11)> (7)> (8)> (6)> (9,16). Furthermore for E.coli the order is (control > 4,13)> (14)> (5,15)> (3,12)> (10)> (11)> (2)> (6,7)> (8,9,16) and also for protteus vulgaris the order is (13)> (10)> (11,12,14)> (15)> control> (5)> (6)> (4,7)> (8)> (3)> (2,16)> (9).Complexes showed enhanced activity in comparison to the standard drug used.


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