New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation

Nassar, Mahmoud Ibrahim; Fikry, Rehab; El-Toumy, Sayed Abdel Hamid; El Hawary, Seham Salah Eldin; Ahmed, Rania; El-Khrisy, Ezzel-Din

doi:10.21608/ejchem.2022.178935.7271

New Glycosylated Flavone and Anthraquinone from Cassia notabilis Randell.: Antidiabetic, Anti-inflammatory and Analgesic Activity Evaluation

Document Type : Original Article

Authors

¹ Natural product chemistry, pharmaceutical institute, NRC.

² Natural Compounds Chemistry Department, National Research Centre, Dokki, Giza, Egypt

³ Chemistry of Tannins Department, National Research Centre

⁴ Pharmacognosy Department, Faculty of Pharmacy, Cairo University

⁵ Pharmacology Department, National Research Centre

⁶ Natural Compounds Chemistry, National Research Centre

10.21608/ejchem.2022.178935.7271

Abstract

The phytochemical investigation of the leaves of Cassia notabilis Randell. revealed the isolation of two new glycosides, identified as 6-methoxyapigenin-4`-methyl ether 7- O-α-L-rhamnopyranoside-8-C-β-D-glucopyranoside (1) and 1,7,8-trihydroxyanthraquinone 3-O-β -D-glucopyranoside (7), along with apigenin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (2), acacetin 7- O-α-L-rhamnopyranoside (3), luteolin 7-O- β-D-glucpyranosyl-(1→6)-β-D-glucopyranoside (4), luteolin 7-O- β-D-glucpyranoside (5), diosmetin 7- O-α-L-rhamnopyranoside (6). The structures of the isolated compounds were established by chromatographic and spectroscopic evidences. Pharmacological studies showed that the three doses of 70% aqueous methanolic extract of C. notabilis leaves (125, 250 and 500 mg/kg) have antidiabetic, analgesic, anti-inflammatory and antioxidant activity.

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