Phytochemical Composition and Anti-SARS-CoV-2 Activity of Leaves Methanolic Extract of Silybum marianum.

Document Type : Original Article

Authors

1 Phytochemistry and Plant Systematics Department, National Research Centre, El-Dokki, Cairo Egypt.

2 Department of Phytochemistry and Plant Systematics, Pharmaceutical and Drug Industries Research institute, National research center, Cairo, Egypt

3 National Research center, DOKKI, Cairo, Egypt.

4 national research center

5 phytochemistry and plant systematic departement,National Research Centre

Abstract

In line with the global interest and demand in finding sustainable ways to counteract the emerging viral pandemics, our study highlights the unique composition and anti- SARS-CoV-2 activity of a barely used and studied part of the famous medicinal plant Silybum marianum (L.) Gaertn. Various chromatographic and spectroscopic techniques used in the process of isolation and structure elucidation led to the identification of nine flavonoids for the first time from the methanolic leaves extract. Among them, the aglycone acacetin (2) was isolated for the first time from the genus. The antiviral activity of the extract against SARS-CoV-2 main protease showed considerable activity with half-maximal inhibitory and cytotoxic concentrations; IC50=80.5 µg/ml and CC50=576.5 µg/ml, respectively indicating a relatively high selectivity; SI = 7.1.

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History

  • Receive Date: 27 November 2022
  • Revise Date: 19 December 2022
  • Accept Date: 20 December 2022

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