Spectrophotometric Determination of Mesalazine via Diazotization-Coupling Reaction by Using Thymol Reagent

Document Type : Original Article

Authors

1 Dept.of Chemistry, College of Education for girls, Mosul University, Iraq

2 Department of Chemistry, college of Education for girls, University of Mosul , Mosul, Iraq

3 Branch of Basic Science, College of Agriculture and Forestry, Mosul University, Iraq

Abstract

A simple and sensitive spectrophotometric method has been developed to determine Mesalazine in aqueous solution. The method depends on reaction of Mesalazine with thymol reagent to afford a colored analogue that has absorption band at 436 nm with molar absorptivity of 4149.95 L.mol-1.cm-1. The determination rang was 2-70 µg/ml with recovery 102.4 and relative standard of less than 1.5 %. The proposed method is applied for determination of Mesalazine in pharmaceutical preparation.

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Egyptian Journal of Chemistry
Volume 65, Issue 132 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part B)
December 2022
Pages 1561-1566

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History

  • Receive Date: 18 April 2022
  • Revise Date: 14 May 2022
  • Accept Date: 16 May 2022

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