Design, Synthesis, and biological evaluation of a novel series of thiazole derivatives based on pyrazoline as anticancer agents

Document Type : Original Article

Authors

1 Applied Organic Chemistry depatment

2 Department of Photochemistry, National Research Centre, Cairo, Egypt

3 Therapeutic Chemistry Department, National Research Centre, Cairo, Egypt.

4 4Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo 11754, Egypt

Abstract

This study deals with the design and synthesis of new pyrazoline-thiazole scaffold as promising anti-cancer agents, with the goal of building new compounds with combinations of various heterocyclic moieties. The pyrazoline-thiazole scaffold was synthesized via cyclization of the chalcone derivatives with thiosemicarbazide to afford the corresponding thioamide 5, which was the key precursor for synthesis of the compounds 7-15. Three cancer cell lines (MCF-7, HepG-2 and A549) were used to examine in vitro anticancer activities of the recently synthesized compounds. Three compounds 7c, 9c, and 11d were found to show the most promising anti-cancer activity against three cell lines.

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Egyptian Journal of Chemistry
Volume 65, Issue 132 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part B)
December 2022
Pages 1241-1252

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History

  • Receive Date: 24 August 2022
  • Revise Date: 08 September 2022
  • Accept Date: 18 September 2022

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