Design, Synthesis, Molecular Docking of Some New Polyhydrobenzothieno￾thiazolopyrimidinedione Glycoside Derivatives with Double Anti-microbial-Anti￾inflammatory Action

Morsy, Nesrin M.; Abu-Zied, Khadiga M.; Aly, Ahmed S.; Elgamal, Abdelbaset M.

doi:10.21608/ejchem.2022.155556.6714

Design, Synthesis, Molecular Docking of Some New Polyhydrobenzothienothiazolopyrimidinedione Glycoside Derivatives with Double Anti-microbial-Antiinflammatory Action

Document Type : Original Article

Authors

¹ Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Dokki, 12622, Egypt.

² Photochemistry Department, National Research Centre , Cairo, Dokki, 12622, Egypt.

³ Departement of Chemistry of Microbial and Natural Products , National Research Centre, Cairo, Dokki, 12622, Egypt.

10.21608/ejchem.2022.155556.6714

Abstract

A novel series of thienopyrimidinone glycoside derivatives 7a–e or 8a–e were synthesized from the reaction of 2- mercapto-theino-pyrimidinone derivtives 3 and 4 or theino-thiazolopyrimidinone 5 and 6 with different aldo-sugars either hexoses or pentoses, The structure of new resulted compounds were elucidated using IR, 1HNMR, 13CNMR and elemental analysis. The compounds 2a, 2b,3,4,7a-e and 8a–e were screened against seven pathogenic bacteria and one fungus using Cprofloxacin and Bavistin as standard respectively. Also, measurement of Minimum Inhibitory Concentration (MIC) was made showing that compounds 2a, 7a and 7d had the height results and near to the standard. Anti-inflammatory study was made for the fourteen compounds against Lipoxygenase “LOX”,cyclooxygenase “COX 1” cyclooxygenase “COX 2” which revealed that compounds 2a, 7a and7d have the best values among the series and good results when compared with the standard. Ipubrofen and indomethacin. Moreover molecular docking studies were done on the three compounds 2a, 7a and7d. This study confirmed the dual action of our compounds as antimicrobial and anti-inflammatory agents

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