Toxicity study of methanol extract of Rosa damascena trigintipetala in mice

Sabra, Abdel-Nasser; Bazaid, Salih; Saleh, El Sayed

doi:10.21608/ejchem.2022.146123.6358

Toxicity study of methanol extract of Rosa damascena trigintipetala in mice

Document Type : Original Article

Authors

¹ Pharmacology Department, Theodor Bilharz Research Institute, Kornish El-Nile-Warrak El-Hadar, Imbaba, Giza 12411, Egypt.

² College of Sciences, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia

³ Medicinal Chemistry Lab., Theodor Bilharz Research Institute, Giza, Egypt

10.21608/ejchem.2022.146123.6358

Abstract

Rose is one of the most important ornamental plants, with economic and cultural importance. In this work, the methanol extract of Taif rose (Rosa damascena trigintipetala Dieck) was investigated for its toxicity (Acute, Sub-chronic and Chronic) and long-term side effects. Also, the effect of dose accumulation on physiological parameters and histopathological changes in normal mice was studied. The results of this study showed that no toxicity indication of methanol extract of Taif rose during acute, sub-chronic and chronic periods on physiological parameters while the pathological studies showed minimal changes in the vital organs. From this work, it is clear that Taif rose methanol extract could be utilised as a good natural, affordable, and safe therapy.

Keywords