An Eco-Friendly Method for Voltametric Determination of Prucalopride Succinate on simple nanoparticles Modified Carbon Paste Electrode

Eleryan, Rasha Th.; Salem, Mohamed; Tony, Rehab

doi:10.21608/ejchem.2022.137778.6062

An Eco-Friendly Method for Voltametric Determination of Prucalopride Succinate on simple nanoparticles Modified Carbon Paste Electrode

Document Type : Original Article

Authors

¹ Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt

² Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Modern University for Technology and Information, Cairo, Egypt.

10.21608/ejchem.2022.137778.6062

Abstract

An eco-friendly, novel, rapid, accurate and precise voltammetric method for the determination of Prucalopride succinate (PRU) in drug substance and dosage form. The drug showed anodic oxidation peak at a potential of 0.989 V using Zirconium oxide nanoparticles modified carbon paste electrode (2%ZrO2/CPE) as suitable electrochemical transducer in phosphate buffer of pH 6. Voltammetric peaks which were diffusion controlled, have been recorded and the experimental conditions including change in pH, different electrode modifiers, different buffer solutions, effect of different types of surfactants and scan rates were all optimized. The peak current showed good linearity and sensitivity over the concentration range of 4.03 x10-7 to 2.20 x10-6 mol.L-1 with 0.9992 correlation coefficient. The limit of detection and limit of quantitation were found to be 9.23x10-8 mol.L-1 and 2.80 x 10-7 mol.L-1, respectively. The prospective validated method was successfully used for the evaluation of (PRU) in dosage form without the interference of the excipients with recovery (%) ± % RSD of 100.52 ± 1.29. All validation parameters were measured according to ICH guidelines.

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