Spectrophotometric Determination of Loratadine drug by New 6-hydrazineyl-3-(pyridiin-4-yl)-[1,2,4] triazolo[3, 4-b][1, 3 ,4]thiadiiazole A1 derived from isonicotinic acid in pure and pharmaceuticals formulation

Document Type : Original Article

Authors

1 department of chemistry, college of education, university of Tikrit

2 Department of chemistry/College of Education for Pure Science / Tikrit University /Iraq

Abstract

A novel, sensitive, simple, and accurate spectrophotometric technique for the determination of Loratadine (LD) drug in pure and pharmaceutical formulations was developed. It was created by the reaction of (LD) and a new organic reagent (A1) prepared from (TCH) and (A) in a base medium. TCH was prepared by heating at reflux of a mixture of carbon disulfide and aqueous hydrazine, while (A) was prepared by thermal melting of a mixture of TCH and nicotinic acid. The absorption of the product of LD and A1 was measured at 466 nm. Linearity ranged between (0.625-30μg.mL-1), molar absorptivity was (17918.92 L / mol.cm), limits of detection and quantification were (0.0705, 0.213 μg.ml-1), respectively. The method was applied successfully for the determination of LD in pure and pharmaceutical formulations.

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Egyptian Journal of Chemistry
Volume 65, Issue 132 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part B)
December 2022
Pages 273-280

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History

  • Receive Date: 15 February 2022
  • Revise Date: 26 June 2022
  • Accept Date: 24 July 2022

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