Document Type : Original Article
Authors
1
Head of Department of Phytochemistry and Plant Systematics, Pharmaceutical Industries institute ,National Research Center, El Buhouth st., Dokki Dokki, Cairo, Egypt
2
Department of Phytochemistry and Plant Systematics, Pharmaceutical Industries institute , National Research Center, El Buhouth st., Dokki, Cairo, Egypt
3
Nature Conservation Sector, Biodiversity Administration, Cairo, Egypt
4
Therapeutic Chemistry Department , Pharmaceutical Industries institute , National Research Centre, El Buhouth st., Dokki, Cairo, Egypt
Abstract
The medicinal plant, Capparis sinaica veill. growing in Al-Tofaha valley, Saint Catherine, South Sinai, Egypt , it belongs to the family Capparaceae ,which has a few purposes in folk medicine for a long time. The preliminary phytochemical screening of the plant, revealed the presence of tannins, flavonoids, glycosides , sterol, saponins and alkaloids. In this study, the methanolic extract of aerial part of Capparis sinaica veill. was carried out by using HPLC analysis which revealed the presence of 15 bioactive phenolic compounds. The rutin is the major compound in the plant. Moreover, the ameliorative effect of the methanolic extract from C. sinaica towards the [500 miroliter of CCl4]-induced hepatotoxicity in male Wistar rats were investigated. The CCl4-treated rats showed a significant decline in the serum levels of high-density lipoprotein (HDL), albumin (ALB) as well as the hepatic levels of glutathione (GSH) and activities of catalase (CAT), superoxide dismutase (SOD) , glutathione reductase (GR), in addition to elevation in the levels of total lipids (TL), triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), globulin (G), total bilirubin (TBil) , alanine and aspartate aminotransferase and alkaline phosphatase (ALAT and ASAT, ALP) and the hepatic levels of malondialdehyde (MDA) were recorded. The administration of methanolic extract of the aerial part of Capparis sinaica, notably improved all the studied parameters. This study showed that CCl4 administration to Wistar rats, at a high dose, could induce a hepatic injury in addition to certain metabolic alterations. The study was extended to investigate tissue histopathology.
In conclusion, the methanolic extract of aerial part of Capparis sinaica may function as a good candidate for the treatment or prevention of liver failure. However, further investigations are required to unveil the molecular identification of the active ingredients and elucidation of the mechanisms involved in the effect.
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