Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines

Document Type : Review Articles

Authors

1 Department of Chemistry, Faculty of Science, Zagazig University, Egypt.

2 Department of Chemistry, Faculty of Science, Zagazig University, (Egypt)

3 Department of Chemistry - Zagazig University - Zagazig- Egypt

4 Chemistry Department, Faculty of Specific Education. Zagazig University

Abstract

Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15.

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History

  • Receive Date: 28 June 2022
  • Revise Date: 03 July 2022
  • Accept Date: 11 July 2022

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