Antibiotics Immobilized Gelatin Nano Carrier Influences on Brucella melitensis Filed Strain

Document Type : Original Article

Authors

1 Microbiology Department, Faculty of Agriculture, Ain Shams University

2 Agric. Microbiology Dept, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.

3 Department of Brucellosis Research, Animal Health Research Institute, Agricultural Research Center, Egypt.

Abstract

Abstract:

Drug delivery system refers to combination of nanotechnology and drugs to improve the ability of targeting specific cell or tissue. About 90 guinea pig animals allocated into two main groups the first group (n=45) infected artificially with Brucella melitensis b.v3 and second group remained as normal control group. Infected animals subdivided to tow treated groups. First one treated with immobilized antibiotics Doxycycline and Streptomycin in gelatin nanocarrier and other group with combination of the antibiotics in traditional form. Three and fourteen days post the end of each treatment course the animals from each group under investigation were weighted and slaughtered .We used the weight of spleen and liver , Brucella C.F.U counts from these organs furthermore liver and kidney functions to evaluate success of treatments .gelatin drug delivery system improve its capabilities against Brucella by reducing colonies forming units number p< 0.05 in infected treated animals if compared with non-infected non-treated group and p< 0.01 in infected treated animals by traditional treatment if compared with infected non treated animals control groups. None of the two treatments could completely eliminate Brucella infection from infected treated animals. So, we recommend to apply more other trials for Brucella infection scaling back.

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Egyptian Journal of Chemistry
Volume 65, Issue 132 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part B)
December 2022
Pages 245-254

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History

  • Receive Date: 30 May 2022
  • Revise Date: 14 June 2022
  • Accept Date: 28 June 2022

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