Synthesis, Reactions, and Antimicrobial Evaluation of 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives

Document Type : Original Article

Authors

1 Department of Clinical Laboratories, College of Applied Medical Sciences, University of  Kerbala, Kerbala, Iraq

2 College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq

3 Organometallic and Organometalloid Chemistry, Chemical Industries Research Institute, National Research Centre

Abstract

New 2-(1,3-dioxoisoindolin-2-yl)acetohydrazide derivatives were synthesized, characterized and evaluated as antimicrobial agents. Phathalic anhydride was reacted with aminoacetoactate to afford phthalimide derivative which reacted with hydrazine hydrate to give new indolinylacetohydrazide derivative 1. Compound 1 is used as precursor to synthesize various derivatives depending on types of reactants. Spectroscopic and analytical measurements are used to confirm structures of new products. Antimicrobial evaluation of new derivatives was done

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History

  • Receive Date: 05 May 2022
  • Revise Date: 26 May 2022
  • Accept Date: 04 June 2022

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