Synthesis, Anticancer and Antimicrobial Activities of New 6-(1H-1,2,3-Triazol-4-yl)imidazo[2,1-b]thiazoles

Document Type : Original Article

Authors

1 Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Center, Dokki, Giza, 12622 Egypt

2 Tanning Materials and Leather Technology Department, National Research Centre, Egypt

3 Pharmaceutical and Drug Industries Research division

4 Applied organic chemistry Department; National Research Centre; Egypt

Abstract

Novel 6-(1H-1,2,3-triazol-4-yl)-imidazo[2,1-b]thiazoles 8-10 were synthesized in good yields by Claisen–Schmidt reaction of the active methylene compounds such as pyrazol-5-one 5, 1,3-indandione 6 and benzoylaceteonitrile 7, with imidazo[2,1-b]thiazol-5-aldehydes 4 in basic medium. Anti-tumor activities in vitro against HepG-2, PC-3 and HCT-116 human carcinoma cell lines were tested for new products. Both compounds 9a and 9b showed antitumor activity comparable to that of positive control (Doxorubicin®). Also, the antimicrobial activities of novel compounds were evaluated. Amongst the tested compounds 9a, 9b, and 10 exhibited excellent antimicrobial activity.

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History

  • Receive Date: 13 May 2022
  • Revise Date: 24 May 2022
  • Accept Date: 29 May 2022

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