Synthesis of Some Novel Pyridine, Sulfonamide, Coumarin and Thiophene Derivatives

Al-Sabawi, Ammar H.; Younis, Shahla A.; Saeed, Rana A.

doi:10.21608/ejchem.2022.135732.5979

Synthesis of Some Novel Pyridine, Sulfonamide, Coumarin and Thiophene Derivatives

Document Type : Original Article

Authors

¹ Department of Chemistry, College of Science, University of Mosul, Mosul, IRAQ

² Department of Pharmaceutical, Mosul Technical Institute, Northern Technical University, Mosul, IRAQ.

10.21608/ejchem.2022.135732.5979

Abstract

A series of novel pyridine, sulfonamide, coumarin, thiophene, α,β-unsaturated carbonyl compounds, and pyrazole derivatives were synthesized from hydrazide-hydrazone derivatives with different reagents (substituted benzaldehydes, hydrazine hydrate, malononitrile, 2-hydroxy-1-naphthaldehyde, tetralone, cyclopentanone, and ethyl cyanoacetate). Hydrazide-hydrazone derivatives were prepared by reactions 2-cyanoacetohydrazide with 2-acetylpyridine or 4-acetyl-N-(p-tolyl)benzenesulfonamide. On the basis of their spectral information, the structures of the newly synthesized chemical derivatives were determined.

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