Spectrophotometric Determination of Carvedilol via Oxidation and Bleaching Color of Methyl Red

Document Type : Original Article


1 College of Education for Pure Sciences University of Mosul

2 Mosul univercity

3 Collage of pharmacy/University of Mosul


A selective spectrophotometric method for the determination of carvedilol (CAR) by oxidation and bleaching reactions in pure and pharmaceutical forms has been described. The method is based on the oxidation of CAR by known excess of ceric (IV) in acidic medium, exceed amount of the last was used in bleaching methyl red dye (MRD) color. The absorption of residual MRD at 520nm is directly proportional to the increase in carvedilol concentration. Beer's law was obeyed over the concentrations from 0.5 to 50 μg ml-1 The molar absorptivity was 1.11381 × 104 l.mol-1.cm-1. Sandell indexes was 0.03610124 μg.cm-2. The proposed method was successfully applied for determination of CAR in tablets.


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