Characterization, Antimicrobial and Antitumor Investigation for Substituted Cyclodiphosph(V)azane sulfa medicines and their Transition Metal Complexes.

Albohy, Salwa A.H.; Taha, Rania H.; Sharaby, Carmen M.

doi:10.21608/ejchem.2022.136363.6007

Characterization, Antimicrobial and Antitumor Investigation for Substituted Cyclodiphosph(V)azane sulfa medicines and their Transition Metal Complexes.

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science(Girls), Al-Azhar University, Nasr City, Cairo,P.O: 11754 Egypt

² College of Science, Jouf University, , Sakaka, Saudi Arabia Postal code:. Box: 2014.

10.21608/ejchem.2022.136363.6007

Abstract

A ligand of geminal cyclodiphosph(V)azane derivatives, 1,3-di-[N-2,6-dimethoxy-4-pyrimidnylsulfanilamide]-2-sulfanilamidopyrimidine]-2,4-dichlorocyclo-diphosph(V)azane(H4L) was prepared. The ligand was reacted with several transition metals such as ferric (III), manganese (II), cobalt (II), copper (II), zinc (II) and cadmium (II) chloride and uranium (II) nitrate in a 1:2; L: M mole ratio to produce colorful complexes in a good yield. Diffraction investigations approaches were used to analyze the ligand and its transition metal complexes, including elemental composition and UV-vis, infrared spectra (IR), 1H NMR, magnetic susceptibility, molar conductance, solid reflectance, thermal analysis, and X-ray powder diffraction investigations. The ligand has an ionic character and coordinates with the metal ions via enolic OH of the sulphonamide group and pyrimidine–N according to the spectrum data. Data on molar conductance reveals that the complexes were electrolytes, according to UV-vis, magnetic moment, and solid reflectance. It has been shown that the complexes have octahedral geometry. The antibacterial activity of the ligand as well as its metal complexes ranged from high to medium against different fungi as well as strains of bacteria, and also demonstrated an anticancer effect against colon carcinoma HCT116.

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