Synthesis, studying analytical properties and biological activity of new transition metal complexes with sulfadiazine derivative as reagent

Abbas, Ghusoon Jawad; Mosaa, Zaied; Radhi, Ali Jabbar; Abbas, Hayder Kadhim; Najem, Walaa Mohammed

doi:10.21608/ejchem.2022.104212.4814

Synthesis, studying analytical properties and biological activity of new transition metal complexes with sulfadiazine derivative as reagent

Document Type : Original Article

Authors

¹ Branch of Biochemistry, Faculty of Medicine,Jabir ibn Hayyan Medical University

² College of science for women, University of Babylon, Hilla, Iraq.

³ Faculty of Pharmacy, Al-Kafeel University, Najaf, Iraq.

⁴ College of Pharmacy, University of Al-Kafeel, Najaf, Iraq.

10.21608/ejchem.2022.104212.4814

Abstract

A new of nickel(II) and copper(II) complexes of 4-((4-acetylphenyl)diazenyl)-3-amino-N-(pyrimidin-2-yl) benzenesulfonamide (SDA) derived from sulfadiazine have been prepared and identified by FTIR, NMR, mass spectroscopy, UV-Visible spectroscopy, and elemental analysis. Also tested to evaluated their activities as antibacterial agents. The spectroscopic and analytical data suggest all prepared nickel(II) and copper(II) complexes a square planar geometry. The agar well diffusion method was used to test the target ligand and their Ni(II) and Cu(II) complexes for antibacterial activity against Gram (+) and Gram (-) bacteria.

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