Synthesis, studying analytical properties and biological activity of new transition metal complexes with sulfadiazine derivative as reagent

Document Type : Original Article


1 Branch of Biochemistry, Faculty of Medicine,Jabir ibn Hayyan Medical University

2 College of science for women, University of Babylon, Hilla, Iraq.

3 Faculty of Pharmacy, Al-Kafeel University, Najaf, Iraq.

4 College of Pharmacy, University of Al-Kafeel, Najaf, Iraq.


A new of nickel(II) and copper(II) complexes of 4-((4-acetylphenyl)diazenyl)-3-amino-N-(pyrimidin-2-yl) benzenesulfonamide (SDA) derived from sulfadiazine have been prepared and identified by FTIR, NMR, mass spectroscopy, UV-Visible spectroscopy, and elemental analysis. Also tested to evaluated their activities as antibacterial agents. The spectroscopic and analytical data suggest all prepared nickel(II) and copper(II) complexes a square planar geometry. The agar well diffusion method was used to test the target ligand and their Ni(II) and Cu(II) complexes for antibacterial activity against Gram (+) and Gram (-) bacteria.


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