New Derivatives from 4-Amino Anti-Pyrine and Vanillin, Synthesis Characterization and Antibacterial Activity

Document Type : Original Article


1 Department of Chemistry, Faculty of Science, University of Kufa, Iraq

2 Ministry of Education, Al-Najaf, Iraq

3 Department of Biology, Faculty of Science, University of Kufa, Iraq


Schiff base, Azo-Schiff base, nickel (II), and copper (II) complexes have been prepared successfully from 4-amino antipyrine and vanillin and diagnosed by UV-visible, FT-IR, 1H-NMR, and 13C-NMR. The derivative compound Azo-Schiff with a 200 mg/ml concentration has good antibacterial activity with a diameter of inhibition zone 16.11 ± 0.1035 mm and 13.21 ± 0.4044 against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), respectively. Therefore, this compound may be considered a raw material for manufacturing treatments against these bacterial infections.


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