Synthesis, Characterization, and biological activity of some Heterocyclic compounds that derived from Ibuprofen

Document Type : Original Article

Authors

1 Department of Science, College of Basic Education/Shirqat, Tikrit University, Tikrit, Iraq

2 Department of Chemistry, College of Science, University of Misan, Maysan, Iraq

Abstract

A simple, easy method for preparation of new thiazoldine derivatives was done and new compound were elucidated on bases of spectroscopic analyses. Ibuprofen reacted with hydrazine hydrate to afford hydrazide derivative which reacted with aldehydes to afford Schiff bases that cyclized with Thioglycolic acid to afford thiazolidine derivatives. Antimicrobial activity of new compounds was carried out using diffusion plate method.

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History

  • Receive Date: 22 April 2022
  • Revise Date: 30 April 2022
  • Accept Date: 04 May 2022

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