Document Type : Original Article
Authors
1
Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia
2
Departement of Pharmacy, Faculty of Pharmacy, Halu Oleo University, Kendari, South East Sulawesi, Indonesia
3
Departement of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar South Sulawesi, Indonesia
4
Pusdaya Indonesia, Kendari, South East Sulawesi, Indonesia
5
Department of Pharmacy, Faculty of Pharmacy, Halu Oleo University
6
Departement of Pharmacy, Faculty of Medicinal, Lampung University, Lampung, Sumatera, Indonesia
7
Departement of Pharmacy, Sekolah Tinggi Ilmu Farmasi Makassar, South Sulawesi, Indonesia
Abstract
The objectives of this research were to formulate theophylline nanoparticles matrix transdermal patch with different ratios of hydroxypropyl methylcellulose and ethylcellulose polymer with ratio 90%:10% (F1), 80%:20% (F2), 70%:30% (F3), 60%:40% (F4), 50%:50% (F5), and to evaluate the physicochemical characteristic of the resulted matrix patch. Preparation of matrix patch was conducted by the solvent evaporation casting method. Physicochemical characteristics of the patch, including physical appearance, weight uniformity, thickness uniformity, pH, moisture content, tensile strength, and profile release, were evaluated. Permeation of drugs into the skin was assessed using a modified Franz diffusion cell. Observations of the physical appearance showed that matrix patches were transparent, smooth, and dry. Weight uniformity ranges were from 0.69 g to 0.77 g with thickness 0.14 mm to 0.22 mm. Moisture content ranges were 0.49% to 2.14%, and pH values were from 5.0 to 6.0. Tensile strength ranged between 1.19 and 3.41 N/mm2. Theophylline release of F1-F5 formulation was varied from 14.46% to 18.62% at 360 minutes, and all patches were capable of permeating through the rat skin membrane. Physicochemical evaluation of matrix patches showed that all patches fulfill the requirements of acceptable patches for transdermal administration.
Keywords
Main Subjects
)
View on SCiNiTO