Antialopecia Activity and IR-Spectrometry Characterization of Bioactive Compounds From Sansevieria trifasciata P.

Document Type : Original Article

Authors

1 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo

2 Department of Analytical Pharmacy and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran

3 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

4 Department of Analytical Pharmacy and Medicinal Chemistry, Faculty of Pharmacy, Universitas Halu Oleo

5 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo

Abstract

Androgenetic Alopecia (AGA) causes more than 90% of alopecia cases. Drugs for the treatment of AGA have toxic and side effects, so it is necessary to find new drugs from the natural product, such as Sansevieria trifasciata. This study aims to determine the hair growth activity of subfraction from Sansevieria trifasciata and characterize the isolate using infrared spectroscopy. The fraction of Sansevieria trifasciata was separated using column chromatography. The hair growth activity using the modified Tanaka method. Skin biopsies of each rabbit stained with hematoxylin and eosin. The characterization of the isolate using infrared spectroscopy (FT-IR). The separation of fractions obtained six subfractions. The hair growth activity from subfraction-C was higher with the hair growth length of 2.80 cm ± 0.00 (p

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Egyptian Journal of Chemistry
Volume 65, Issue 132 - Serial Number 13
Special Issue: Chemistry and Global Challenges (Part B)
December 2022
Pages 19-24

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History

  • Receive Date: 05 November 2021
  • Revise Date: 06 January 2022
  • Accept Date: 20 April 2022

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