Heterocyclization of Thiourea Derivative to Novel Azines and Azoles: Antioxidant and Antimicrobial studies

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Zagazig University, Egypt.

2 Department of Chemistry, Faculty of Science, Zagazig University, (Egypt)

3 Department of chemistry, faculty of science, Zagazig university

4 Department of chemistry, faculty of science, Zagazig university, Egypt

Abstract

N,N'-disubstituted thiourea derivative 2 underwent oxidative cyclization with Br2/AcOH mixture to give thiazole 3.Thiadiazole 6 was obtained as the result of chlorination of 2 followed by amination and subsequent intramolecular cyclodehydraration. Thermal treatment of N,N'-disubstituted thiourea derivative 2 with TEA in DMF resulted in hydrolysis of 2 to furnish thiourea derivative 8. Treatment of compound 8 with semicarbazide, thiosemicarbazide, diethyl succinate, diethyl malonate / benzaldehyde or urea resulted in the formation of triazoles 11a,b, pyrrole 13, thiazine 16 and oxathiazole 19. The newly synthesized compounds were tested for their antioxidant and antimicrobial activities.

Keywords

Main Subjects

Files

Cited by

History

  • Receive Date: 07 April 2022
  • Revise Date: 10 April 2022
  • Accept Date: 15 April 2022

Share

How to cite

Statistics