Heterocyclization of Thiourea Derivative to Novel Azines and Azoles: Antioxidant and Antimicrobial studies

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Zagazig University, Egypt.

2 Department of Chemistry, Faculty of Science, Zagazig University, (Egypt)

3 Department of chemistry, faculty of science, Zagazig university

4 Department of chemistry, faculty of science, Zagazig university, Egypt

Abstract

N,N'-disubstituted thiourea derivative 2 underwent oxidative cyclization with Br2/AcOH mixture to give thiazole 3.Thiadiazole 6 was obtained as the result of chlorination of 2 followed by amination and subsequent intramolecular cyclodehydraration. Thermal treatment of N,N'-disubstituted thiourea derivative 2 with TEA in DMF resulted in hydrolysis of 2 to furnish thiourea derivative 8. Treatment of compound 8 with semicarbazide, thiosemicarbazide, diethyl succinate, diethyl malonate / benzaldehyde or urea resulted in the formation of triazoles 11a,b, pyrrole 13, thiazine 16 and oxathiazole 19. The newly synthesized compounds were tested for their antioxidant and antimicrobial activities.

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History

  • Receive Date: 07 April 2022
  • Revise Date: 10 April 2022
  • Accept Date: 15 April 2022

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