Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate

Mahmoud, Shimaa A.; Taha, Mohamed; Khaled, Eman S. H.; Abdel-khalek, Ahmed A.; Mohamed, Reham A.

doi:10.21608/ejchem.2022.125128.5563

Kinetics and mechanism of the oxidation of chromium (III) complex involving the antifibrinolytic drug Tranexamic acid by periodate

Document Type : Original Article

Authors

¹ Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

² Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt.

³ Chemistry department, faculty of science, Beni-Suef university, Beni-Suef, Egypt

10.21608/ejchem.2022.125128.5563

Abstract

Tranexamic acid (TXA) have antifibrinolytic properties and finds wide applications in pharmaceuticals, most used in cardiac, orthopaedic, urological, gynaecological, and obstetric surgery. Complexes of tranexamic acid with some metal ions show antimicrobial and anti-tumor activity. Oxidation-kinetic study is of much importance in understanding the mechanistic profile of Cr-TXA complex in biological systems. Kinetics of oxidation of [CrIII(TXA)(H2O)5]2+ by periodate has been spectrophotometrically studied under pseudo order conditions over 293-313 K, pH (3.20-4.20) range, and ionic strength of 0.30 M for a set of periodate concentrations. The initial oxidation product is certainly Cr(V). The reaction is first order dependent on complex concentration. The pseudo-first order rate constant, kobs increased with decreasing proton concentration, indicating that the deprotonated form of the chromium (III) complex is the reactive species. An inner sphere mechanism has been proposed for the oxidation process. The thermodynamic activation parameters are also reported.

Main Subjects