Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties

Document Type : Original Article

Authors

• Mejdi Snoussi ¹
• Ameni Ghabi ²
• Magdy El-Sadek abid ³
• Abdullah Althunayyan ⁴
• Azda Alassaf ⁵
• Fahad Alminderej ⁵
• Abuzar E. A. E. Albadria ⁵
• Wael A. El-Sayed ^{6, 7}
• Adel Kadri ⁸
• Kais Aouadi ⁹

¹ University of Hail, KSA

² University of Monastir

³ Chemistry Department, College of Sciences & Art, . Jouf University, Saudi Arabia

⁴ Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

⁵ Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia

⁶ Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.

⁷ Photochemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt

⁸ Faculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.

⁹ Department of Chemistry, College of Science, Qassim University, buraidah

Abstract

Keywords

• isoxazolidines
• enantiopure
• chiral nitrone
• drug-likeness
• pharmacokinetics

Main Subjects

• Organic chemistry