Synthesis and biological activity evaluation of some novel heterocyclic compounds incorporating pyridine / chromene moiety

Document Type : Original Article

Authors

1 Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt

2 Chemistry Department, Faculty of Science, Helwan University, Helwan, Egypt

Abstract

4-Bromoacetyl pyridine 2a and 3-bromoacetylcoumarine 2b react with malononitrile 3 and thiourea 6 to afford the furan and the thiazole derivatives 5a,b and 7a,b respectively. The thiazoles 7a,b react with DMFDMA 8, phenyl isothiocyanate 10, acetic anhydride 12 and ethyl cyanoacetate 14 to afford the thiazole derivatives 9-13a,b and the thiazolo[3,2-a]pyrimidinone derivatives 16a,b respectively. All structures are proven by analysis and spectral methods. The biological activity of the synthesized compounds was screened as anti bacterial and anti fungal agents.

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History

  • Receive Date: 13 March 2022
  • Revise Date: 19 March 2022
  • Accept Date: 22 March 2022

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