Characterization of Dry Powder Inhaler Quercetin Solid Lipid Microparticle (SLM) as Lung Delivery System: Effect of Polymer Concentration

Document Type : Original Article

Authors

1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Jl. Mulyorejo Surabaya, Indonesia

2 Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo

3 Pusat Teknologi Keselamatan dan Metrologi Radiasi – BATAN, Indonesia

4 Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo Campus C Jl. Mulyorejo

Abstract

The inhalation route for pulmonary treatment can provide many advantages such as high surface area with fast absorption due to high vascularity, avoiding the first pass effect, therapeutic effect can be achieved at much lower doses, as well as targeted drug delivery so as to reduce side effects. Solid lipid microparticle system containing Quercetin which was formed as Dry Powder using glyceryl behenate as lipid and poloxamer 188 as surfactant polymer was prepared. The system was characterised in terms of moisture content, morphology, particle size, flow properties, aerosolization study, mass median aero dynamic (MMAD) and in vitro release. Size and morphology was spherical and smooth with dry and small size met inhalation size (

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History

  • Receive Date: 05 February 2022
  • Revise Date: 05 March 2022
  • Accept Date: 10 March 2022

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