Beta-cyclodextrin Grafted with Poly (ε-caprolactone) for Ibuprofen Delivery System

Haroun, Ahmed; Osman, Ali; Ahmed, Sayed; Elghandour, Ahmed

doi:10.21608/ejchem.2018.5125.1455

Beta-cyclodextrin Grafted with Poly (ε-caprolactone) for Ibuprofen Delivery System

Document Type : Original Article

Authors

¹ National research centre

² Department of organic chemistry, Faculty of science, Beni-suef University, 62514, Egypt.

10.21608/ejchem.2018.5125.1455

Abstract

The aim of this study is to synthesize a polymeric composite based on grafted beta-cyclodextrin (β-CD) with poly (ε-caprolactone) using ring-opening polymerization (ROP) technique, in presence of ethylene glycol dimethacrylate (EGDMA) and benzoyl peroxide (BP) as crosslinker and initiator, respectively, for drug delivery system (ß-CD-PCL). The obtained ß-CD-PCL composites were characterized by nuclear magnetic resonance (1HNMR), Fourier transform infrared spectroscopy (FT-IR) and transmission electron microscope (TEM). Ibuprofen (IBU) was used as anti-inflammatory drug model. IBU was loaded onto the resulting materials during the preparation process at different drug concentrations (400, 516, 600, 700 and 1000) mg/L. On the other hand, the kinetics study of the copolymerization was carried out in terms of grafting yields (GY%), grafting efficiency (GE%), and monomer conversion (%). Moreover, in vitro IBU release study was investigated in phosphate buffer of pH 7.4 at 37°C. The results indicated that the prepared composites based on grafted β-CD with PCL could be used as a potential hydrophobic drug delivery carrier with sustained release property. Besides, due to the sustained release of IBU from the cavity of the β-CD, it was possible to maintain a constant desired IBU concentration over a period of 24 h, as confirmed by the release steady.

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