Design, synthesis, molecular docking study and toxicological evaluation potential of new spiro and fused heterocycles against agricultural insect pests

Document Type : Original Article

Authors

1 Faculty of Pharmacy, Future University in Egypt, New Cairo 11835, Egypt,

2 Chemistry Department, Science Faculty, Ain Shams University, Cairo, Egypt 11566

3 Chemistry section, School od distance education, University Sains Malaysia, Penang, Malaysia

Abstract

Reactions of 4'-(2-oxo-3-(thiophen-2-ylmethylene)furan-5-yl)acetanilide with amines, carbon nucleophiles and isatin, under various conditions provided a variety of spiro-, fused- and heteocyclic deivatives. The structures of the new compounds were characterized by spectral data and elemental analysis. The larvicidal activities of the synthesized compounds were tested against Plutella xylostella and Helicoverpa armigera larvae in vitro. The molecular docking simulations results towards acetylcholinesterase of Drosophila Melanogaster demonstrated the role of the new compounds as prominent larvicides.

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  • Receive Date: 16 October 2021
  • Revise Date: 18 November 2021
  • Accept Date: 02 December 2021
  • First Publish Date: 02 December 2021