Assessment The effect of prebiotics, probiotics and synbiotics on Hyperlipidemia

Document Type : Original Article


1 Applied research sector .The Egyptian company for production of Vaccines,Sera and drugs .Vacsera

2 Microbiology Department, Faculty of Agriculture, Cairo University, Giza, Egypt.

3 Microbiology Department, Faculty of Agriculture, Cairo University, Cairo, Egypt

4 The International Center for Advanced Researches (ICTAR- Egypt), Cairo, Egypt.


Hypercholesterolemia is a major risk factor for the development of atherosclerosis; a number of pharmacological and non-pharmacological (including dietary) approaches being employed to reduce it. Up until now, the trials to prove the hypocholesterolemia effect of probiotics have not been convincing. There are only few data suggesting that the supplementation of the diet with functional food products containing probiotic bacteria lower LDL-cholesterol (LDL-C) concentration in patients with moderately elevated cholesterol concentration in plasma. The aim of the present study was to evaluate in vitro the anti-atherosclerotic effect of a probiotic (Lactobacillus rhamnosus, casei, plantarum, and reuteri), prebiotic (Flaxseed & Cinnamon, green coffee, ginger, and green tea extracts) & combination mix using MCF-7cell line. Recording data showed that probiotic compound administration to hyperlipidemia: a significant decrease of the total serum cholesterol & triglycerides, a significant increase of the serum antioxidant potential. In conclusion, our data support the administration of probiotic Lactobacillus bacteria and prebiotic and combination to decrease serum cholesterol, triglycerides, and lipid droplets increase the antioxidant potential in hyperlipidemia subjects.


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